Antidepressant therapy can induce mania in bipolar patients if given without a mood stabilizer. That is one common explanation for homicidal and otherwise irrational behavior in patients taking antidepressants... they had bipolar disorder and were misdiagnosed.
------------------------------------------------------------ ------
Shakespeare,
I'm having a lot of trouble with this "explanation".
More than half of Paxil users will have periods of irrational behavior, including homicidal and suicidal thoughts and attempts. So, does this mean that over 5 million people were "misdiagnosed' by their 'medical professional" ?
To me, an unplanned suicide is "irrational behavior". So, what about the THOUSANDS of women who've committed suicide while taking Sarafem (Prozac) for PMS and Entreve (Cymbalta) for "stress induced urinary incontinence" ?
Maybe our "medical professionals" are just a little brain dead when it comes to diagnosing ... and now we have them "diagnosing" our children and writing them prescriptions for legalized COCAINE AND SPEED !!!
Mania includes intensely elevated mood, grandiosity, delusions, racing thoughts, decreased need for sleep, and occasionally psychotic symptoms. Patients in mania can commit all kinds of irrational acts because they have lost contact with reality. I recently read a case study of a patient who slept restlessly one night, woke early, and left for work at the usual time. He came home early in the afternoon and reported to his wife that he had developed a way to keep fish from dying. He had quit his job and spent their entire savings (for children's college) on aquariums and other supplies, and was going to make a fortune by making fish live forever.
Antidepressant therapy can induce mania in bipolar patients if given without a mood stabilizer. That is one common explanation for homicidal and otherwise irrational behavior in patients taking antidepressants... they had bipolar disorder and were misdiagnosed.
Hypomania is a milder form of mania in which the patient maintains contact with reality but is still significantly impaired. Episodes of mania or hypomania can last days to months. The depressive part is fairly self explanatory. There is almost always recurrence of episodes at both end of the spectrum and the suicide rate among bipolars is higher than that for any other mental disorder, including unipolar major depression and schizophrenia. There is substantially more to it, but that is the gist of it. Suffice it to say that it can destroy lives.
shakespeare38631.7120949074 I keep reading these posts about people being diagnosed with "bipolar" disorder. What is it ?manic depression....Sorry I took it wrong. I just responded to you as well, but for the post I'll clarify a little. It used to be believed that low levels of serotonin caused depression in bipolar and high levels of norepinephrine caused mania, and that was supported by measuring the byproducts of these neurotransmitters in the urine during accute episodes.
BUT lithium is our most effective med and has little effect on either of these neurotransmitters. Also, Wellbutrin effects mainly norepinephrine but is the least likely to induce mania. If the "high norepy in mania" theory is accurate, it should be the most likely. Current research is exploring voltage sensitive sodium channels and G-proteins in the brain, both of which can increase/decrease excitement in the brain. The reality is we really don't know, but with new technology we are hoping to find out. Hope that clarifies a little (not that it really answered much!)... 
BTW, your description of mania was beautiful... that is exactly what it feels like. It's an experience I was never able to put words to before....
chjones, I do know what it feels like. I am bipolar as well, and I take 5 different meds just to get through the day. And I know well how alive mania makes me feel, but feeling good didn't keep me out of the hospital on numerous occasions. I also know what it feels like to want to die. I have been in and out of psych wards and chemical dependency treatment centers since I was 17, and even spent a few months living on the street. I know what it means to face adversity. I also know that I have grown from those experiences and have learned to be grateful for them. I can't explain the nature of the illness, but please don't imply that I don't understand. I understand all too well. shakespeare38632.2931712963Welcome mytadd
Glad you are here.
My life has been colored by Bipolar Disorder(Manic Depression) and ADHD. I see both disorders as being a blessing and a curse in my life. "Hypermania" can be pleasant, very euphoric, and one might become aggitated, spend lots of money, speak extremely rapid, and think your "superman" even if your female. Grandious one might be at this time.
Hypomania is very deceptive and I am probably "suffering" from it as I speak. For you see when I start thinking sleep is a waste of time and my mind is starting to kick into overdrive and I start losing prespective on everything, I am already in a place that I might not come back from. Depression is Depression. An excrutiating pain that sucks the life out those it torments. Hopelessness is a very ugly place to be.
But pure mania took me somewhere else this year for the first time. You see throwing my keys and shoes at a moving police vechicle and also dodging cars and city bus to elude my new friends with guns all to get my "Dogs" help is insane. They had a new place for me to stay for a few day which was not that bad compared to the prison of shame associated with this incident. I would like to say ADHD was no blessing that day but I did know where my keys were.
This is my first time time posting so please tell me if I'm out to lunch.
[QUOTE=BALANCED] I keep reading these posts about people being diagnosed with "bipolar" disorder. What is it ?[/QUOTE]
Here's a link that'll explain it.
http://www.adhdnews.com/forum/forum_posts.asp?TID=12157
From what I can make of it, it's not so much bipolar, as bigrizzly.
[QUOTE=Brookelea]manic depression....
you are either really manic or depressed... it fluctuates.. very moody...
[/QUOTE]
Is Davidornado Manic?
http://www.adhdnews.com/forum/forum_posts.asp?TID=12157
Or schizophrenic?
http://www.adhdnews.com/forum/forum_posts.asp?TID=9950&K W=is+davidornado+manic&PN=0&TPN=1
Or just phrenic?
davie boy u crack me up!!!!! hows it going
you might be out to lunch but you are not alone - there are quite a few of us pic-nicking out there with you....
Feb. 7, 2005 — Suicide rates have dropped in association with increased use of selective serotonin reuptake inhibitors (SSRI) and new-generation non-SSRIs, according to the results of an analysis of a U.S. Centers for Disease Control and Prevention (CDC) national vital statistics study published in the February issue of the Archives of General Psychiatry. However, the investigators acknowledge that this type of data cannot demonstrate causal relationships.
"Approximately 30,000 people die annually by suicide in the US," write Robert D. Gibbons, PhD, from the University of Illinois at Chicago, and colleagues. "Although 60% of suicides occur during a mood disorder, mostly untreated, little is known about the relationship between antidepressant medication use and the rate of suicide in the US."
Using data from all US individuals who committed suicide between 1996 and 1998, the investigators extracted national county-level suicide rate data broken down by age, sex, income, and race. They also determined national county-level antidepressant prescription data, expressed as the number of pills prescribed. The main outcome was the suicide rate in each county expressed as the number of suicides for a given population size.
After adjustment for age, sex, race, income, and county-to-county variability in suicide rates, antidepressant medication prescription was not significantly related to suicide rate. However, within individual classes of antidepressants, prescriptions for SSRIs and other new-generation non-SSRI antidepressants, such as nefazodone hydrochloride, mirtazapine, bupropion hydrochloride, and venlafaxine hydrochloride, were associated with lower suicide rates, both within and among counties. There was a positive association between tricyclic antidepressant (TCA) prescription and suicide rate. In rural areas, higher suicide rates were associated with fewer antidepressant prescriptions, lower income, and relatively more prescriptions for TCAs.
"The aggregate nature of these observational data preclude a direct causal interpretation of the results," the authors write. "A high number of TCA prescriptions may be a marker for those counties with more limited access to quality mental health care and inadequate treatment and detection of depression, which in turn lead to increased suicide rates. By contrast, increases in prescriptions for SSRIs and other new-generation non-SSRIs are associated with lower suicide rates both between and within counties over time and may reflect antidepressant efficacy, compliance, a better quality of mental health care, and low toxicity in the event of a suicide attempt by overdose."
shakespeare38631.8593055556BTW, it's Yentreve, not Entreve, and the fact that you think duloxetine, an SSNRI, is related to olanzapine, a dibenzothiazepine antipsychotic, makes any information you present on Cymbalta suspect. I will try to look up estimates of suicides for duloxetine and get back to you. To my knowledge, there were 4 suicides commited during clinical trials, fewer than with Prozac, Paxil, or Zoloft. The question then becomes where do you draw the line between correlation and causation? How many would have commited suicide without the drug? No research can answer that. shakespeare38631.8640046296
You know there are alot of people who go to ER's for help and give there symptoms and when asked about mood disorders in family history's do not always come clean about them, out of embarrassment or they just really don't know. For the Antidepressants that help people it is a god send, think of all the lives that are saved by them. For the one's who have a family history of mood disorders, I feel for them, but you really need to know your family tree and be honest with the doc's. Even if you have to say, "I JUST DON'T KNOW!" Get there advice.
Hey shakes
so shakespeare --- why is that the times when you feel most manic are often the times you feel most alive. that is what i don't understand.
Wow,Chjones,
Now I know what racing thoughts are. 
I mean it, thank you....I had no idea is was like that.

Chjones, 
Was that your description of Mania,
Like I said, either way,
thank you for explaining, Wow!
Yuri!...I justov sn0rtedevsky coffeelenko!!!
Hijole! Yo no sufro de ADHD, lo admiro! Son los demas alredor que sufren...
woo-hoovski!...Ђйє мedѕ áёяn’т щбяkїñg!
Rolling On The Freakin' Floor Laughing My Freakin' Arssey Off Again, Out Freakin' Loud And Grabbing My Sides B/c They Freakin' Hurt!!!
I don't know what's funnier, the sn0rtedevsky or the woo-hoovski!...
I like the Yuri, too, though...
r u drinking?[QUOTE=BALANCED should've]I'm just a little brain dead when it comes to diagnosing ... and now I have them "diagnosing" our children and writing them prescriptions for legalized COCAINE AND SPEED !!![/QUOTE]
How do you figure that Ritalin is legalized coke and ADDerall is legalized amp?
[QUOTE=brig]r u drinking?[/QUOTE]
No. But that was hecka hillarious. I'm still jigglin'!
I should loosen my underclothing. It's affecting
My legalized COCAINE is wearing off.
OMG!...I just insulted unbalanced!!!
[QUOTE=Davidornado][QUOTE=brig]r u drinking?[/QUOTE]
No. But that was hecka hillarious. I'm still jigglin'!
I should loosen my underclothing. It's affecting
My legalized COCAINE is wearing off.
OMG!...I just insulted unbalanced!!!
[/QUOTE]
yes it was hecka hillariass....r u jigglin or wrigglin?
OMG did you snort coffee? or spit milk on ur puter