i have self diagnosed adhd and i would really like to be proven right by a professional, so if you have ADHD then please tell me if these are the symtoms:
im really impulsive, i dont think about what i've done till sometimes a week later, and because im impulsive im now the class clown,
i cannot put myself in other peoples shoes at all and see how my behavior affects them.
i used to smoke dope(weed) and i was wildly violent on it.
im very hyperactive,
i dont need much sleep and i fing it difficult to sleep at all,
and im full of so much frustration its unbelievable!
NO YOU ARE NOT ADHD,,,,,,,THESE COULD APPLY TO ANYBODY.
ARE YOU A CHEMIST OR HOLD THE LICENSING THEREOF, GLEN? OR IS THAT BIG FILTHY MOUTH ALL YOU ARE AND ALL YOU HAVE? LET ME TELL YOU SOMETHING, YOU LITTLE WORM...
I AM NOT ANTI-MED, CAUSE IF YOU HADN'T NOTICED, I GAVE THE DRUG TO MY DAUGHTER FOR 10 YEARS! YOU CAN LOOK UP BENZENE AND RITALIN ALL DAY, YOU AIN'T GONNA FIND IT, YOU THINK THEY'RE GONNA MAKE IT THAT EASY? BUT WHEN YOU INVESTIGATE BENZENE AND RITALIN, YOU WILL FIND IT. GO BACK TO YOUR RX.LIST PAGE IDIOT, AND I'LL EVEN GIVE YOU A CLUE....CLICK ON....
polyethyleneA polymerized resin of ethylene; used to make a wide variety of products, including tubing used in intravenous sets.
AND GO FROM THERE....SEARCH IT OUT, YEAH, GO AHEAD GLEN....ETHYLENE, BENZENE....YES....TRY HARDER GLENNY....
HERE....HOW ABOUT THIS GLENNY....
http://www.humboldt.edu/~morgan/methyl.htm
IF YOU THINK FOR A MINUTE I HAVE TIME TO SIT AND HAVE TEA WITH YOU, YOU ARE DEAD WRONG. I COULDN'T CARE LESS ABOUT THIS TIGHT KNIT LITTLE COMMUNITY - IF ALL YOU ARE IS A BUNCH OF CLOSE MINDED JERKS! BUT GET THIS MUCH STRAIGHT, I HAD A MESSAGE TO SHARE, AND THIS IS AMERICA, I HAVE SHARED IT, AND WHETHER YOU LIKE IT OR NOT, IT'S OUT THERE, AND FRANKLY, I HOPE IT HELPS SOMEONE. DON'T KILL THE MESSENGER BECAUSE YOU DON'T LIKE THE MESSAGE. I REALLY HOPE, THAT NO CHILDREN END UP IN THE CONDITION THAT MY DAUGHTER IS IN. CAN YOU IMAGINE THAT, I WANTED TO SAVE AT LEAST ONE CHILD FROM THIS HORRIFYING EXPERIENCE THAT WE ARE NOW IN. NO, GLEN, I DON'T IMAGINE YOU CAN. GROW UP AND GET A LIFE. OH AND FOR ALL OF YOU WHO THINK THIS JUST HAPPENED TO MY DAUGHTER....WRONG AGAIN! THIS DIDN'T JUST HAPPEN.... THIS WAS DRUG INDUCED....YOU CAN SEARCH THAT OUT TOO! METHYLPHENIDATE CAUSES, ITP, THROMBOCYTOPENIA PURPURA, AND IT'S BENZENE INGREDIENT CAUSES PANCYTOPENIA, APLASTIC ANEMIA AND BASICALLY, LEUKEMIA, CANCER OF THE BONE MARROW. JERK.
THINK METHYLPHENIKILLEM DOESN'T CAUSE ITP? THINK AGAIN!
Attention Deficit Disorder
methylphenidate hydrochloride (Ritalin) thrombocytopenia purpura is listed as a side-effect
http://www.itppeople.com/warnings.htm
YOU KNOW, I DIDN'T COME IN HERE EMPTY HANDED WITH JUST WORDS, I HAD PROOF, ALL YOU HAD TO DO WAS ASK FOR IT, BUT INSTEAD YOU ACT LIKE ANIMALS. PICKEN ME APART.
OR TRY THE PHYCISIAN'S DESK REFERENCE, EVEN THE ONE BACK FROM 1977, CLEARLY READS ITP IS CAUSED BY METHYLPHENIDATE. FROM THERE IT TURNS TO PANCYTOPENIA, APLASTIC ANEMIA....AND ON AND ON.
OR HERE...TRY THE 1991 HOUSEHOLD PRESCRIPTION GUIDE - LOOK UNDER METHYLPHENIDATE - IT CASUES ITP, AND LOW RED AND WHITE BLOOD CELLS.... MOVING RIGHT INTO PANCYTOPENIA.
THINK METHYLPHENIKILLEM DOESN'T CAUSE ITP? THINK AGAIN!
Attention Deficit Disorder
methylphenidate hydrochloride (Ritalin) thrombocytopenia purpura is listed as a side-effect
http://www.itppeople.com/warnings.htm
YOU KNOW, I DIDN'T COME IN HERE EMPTY HANDED WITH JUST WORDS, I HAD PROOF, ALL YOU HAD TO DO WAS ASK FOR IT, BUT INSTEAD YOU ACT LIKE ANIMALS. PICKEN ME APART.
It must be a conspiracy: a search for Benzene +Methylphenidate came up with nothing; not even Ritalin.death has anything to offer.
__________________
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HEY CHECK THIS OUT....http://www.humboldt.edu/~morgan/methyl.htm
Chemistry of methylphenidate
by: Elliott Mcdonough
Methylphenidate is the drug that is used to help
people with Attention Deficit Hyperactive Disorder (ADHD)
and Narcolepsy; the first two reports in this project
should
have discussed both the physiological and behavioral
aspects of this drug. The methylphenidate molecule is
just as interesting as the behavioral and physiological
effects.
This paper will be split into four main parts. The first
section of the paper will be discussing the preparation
of the molecule before it is ready for ingestion. The
second part will talk about the chemical composition of
the drug and some physical data. The third part of the
report will deal with the route that the drug takes once
it has been ingested by the patient. The fourth section
will discuss
the side effects of the drug from a chemical and
physiological standpoint.
The preparation of the drug is a very important when
looking at methylphenidate. The molecule methylphenidate
does not normally dissolve in water because its London
forces (attraction between atoms in a covalent molecule)
are stronger than the dissociation forces of the water
molecule. However, when methylphenidate is treated in a
very dilute solution of hydrochloric acid and this
changes the molecule and its charge. A hydrogen atom
bonds with the one nitrogen atom in the methylphenidate
molecule, location of this action will be discussed in
the chemical composition
section, the effect is that the molecule changes into
what is known as methylphenidate hydrochloride. The
change is also that the methylphenidate receives a
positive charge
from the hydrogen atom as well as the chloride atom
receiving a negative charge. The overall change in the
molecule is that it becomes a salt. The salt is composed
of the methylphenidate + the hydrogen cation, and the
chloride anion; the body treats the methylphenidate as a
normal salt. After ingestion the methylphenidate
hydrochloride dissociate into its cation form,
methylphenidate + hydrogen, and its anion, chloride. This
molecule is easily dissolved in water so it can be
ingested orally and absorbed quickly into the patient’s
system.
This section will talk about the chemical composition
of the drug. The overall molecule is split up into three
main sections. The parent part of the molecule is the
amine. The amine is composed of five carbons and a
nitrogen aligned in a hexagonal formation. Each of the
six main atoms are saturated; that is they form four
bonds and have no free
electrons. One of the carbon atoms forms a bond with
another carbon to reach the two constituents of the
parent. These two carbon atoms will be designated as the
second carbon on the amine and its carbon bond; their
significance will be discussed later in this section.
The carbon outside the amine forms three bonds. The
first is to the benzene ring constituent, the second is
to the carboxylate
constituent, and the third is to a hydrogen molecule.
The benzene ring is formed of six carbons and six
hydrogen. The actual alignment of the atoms is that the
carbons are on the inside of the rings with a hydrogen
bonded to each one on the outside. The carbons have
three double bonds among the six of them; the strange
part about the inner three double bonds is that they are
shared equally by the six carbons. The benzene ring is
also one of the major reasons that methylphenidate has
such strong side effects with certain
prescription drugs like the tricyclics, and the anti
convulsants, and the anticoagulants (rxlist.com). The
last constituent is called the carboxylate constituent.
It is composed of a methyl group (a carbon with three
hydrogen
bonded to it); an oxygen that connects the methyl group
with the carboxyl group. And a carboxyl group; that is a
carbon double bonded to an oxygen.
Methylphenidate appears as a white crystalline
powder. The molecular weight of the drug is 269.80
grams/mole of methylphenidate hydrochloride. The melting
point of the
drug is 224-226 C. It is soluble in such substances as:
water, ethanol at 95% purity, and methanol. All of these
solutions are polar so they can dissociate the molecule
easily. Other solutions that are made up of non-polar
molecules have a harder time dissociating the molecule
because they cannot break the London forces of the
molecules. The chemical formula of the drug is
C14H19NO2.HCl. The percentage breakdown of the
methylphenidate molecule is: 72.07% carbon, 8.21%
hydrogen, 6.00% nitrogen, and 13.72% oxygen. It is
odorless, it is stable under normal lab conditions, and
is slightly acidic to litmus; this makes sense when you
think of the preparation of the drug in dilute
hydrochloric acid. The
LD50 of the drug when administered orally to rat is
367mg/kg (ntp dp.niehs.nih.gov).
Methylphenidate has four possible isomers. These
four isomers are dependent on the position of the number
two carbon in the parent amine and the carbon outside the
amine group. These two carbons are able to form mirror
images of the molecule. Because each carbon can form two
isomers the total number of isomers is four. In order to
prepare the methylphenidate for patients the chemists
must separate all four isomers and then treat that isomer
with the hydrochloric acid.
Now that I have explained the finer details of the
molecule methylphenidate I can move on to the greater
overall effects of the drug. In this section I will be
discussing the route of the drug and the area of the
brain where it has its main effects. Methylphenidate is
a mild Central Nervous System stimulant. It has been
categorized as a Schedule II controlled substance by the
DEA (gsm.com). Methylphenidate is related to the drug
amphetamine and you can see the relationship in their
excitatory effects on the user. The dosage for
methylphenidate comes in three levels: 5mg, 10mg, 20mg.
The factors that determine the dosage level for a patient
using this drug is their age, their body weight, and
their sex. The actual pill comes in two forms the normal
release and the extended release pill that stays in the
patient’s system longer and thus extends the length of
the overall effects of the drug on the user.
Methylphenidate is administered orally and absorbed
rapidly through the Gastrointestinal tract. In one study
the administration of methylphenidate with food increased
the rate with which it was absorbed into the system
(mentalhealth.com). However, it is metabolized rather
quickly due to first pass metabolism and bioavailability
is low, roughly 30%, because of the rapid metabolism of
the drug (mentalhealth.com); the subject variation for
the first pass metabolism is rather high so it can differ
among patients the speed with which the drug takes
effect. The
duration of the action of methylphenidate ranges from 3
to 6 hours for the normal tablets; the range for the
extended release tablets is about eight hours (gsm.com).
The
metabolism of the drug occurs in the liver through the
hydroxylation of methylphenidate to ritalinic acid (alpha
phenyl 2 piperidine acetic acid, PPAA) (gsm.com).
Methylphenidate is almost completely released from the
body through the urine of the user. About 97% of the
dose being released as metabolites in the urine within 90
hours after ingestion; roughly less than 1% is released
as unchanged methylphenidate in urine (gsm.com). About
3% of the
methylphenidate is excreted in the feces.
Methylphenidate and its metabolites are distributed
in the blood in erythrocytes and plasma. The total
percentages of distribution is 57% in plasma and 43% in
erythrocytes; the drug also exhibit low protein binding
(mentalhealth.com). "Peak plasma concentrations of 10.8
and 7.8 ng/mL were observed on average, 2 hours after
administration of 0.30 mg/kg in children and adults,
respectively" (mentalhealth.com). The results from the
peak plasma concentration showed a large variability
among the patients. Methylphenidate has a half life in
the plasma of 2.4 hours in children and 2.1 hours in
adults; both of these results were found from the 0.30
mg/kg dose. It appears that the drug is similar to
amphetamines in the specificity of location of action in
the CNS; however, methylphenidate seems to have more of
an effect on mental activities than amphetamines.
Methylphenidate seems to stimulate the brain stem arousal
system and the cerebral cortex (rxlist.com). The drug’s
action on the CNS is not yet fully understood, but its
primary sites of action seem to be in the
dopaminergic neurons. It seems to block the re uptake of
this neurotransmitter, thus creating an increase in
activity of dopamine in the CNS. The physiological
result is an increase in motor activity and an increase
in mental
alertness (gsm.com). "The action of methylphenidate
results in a decrease in hyperactivity and an increase in
the child’s attention span" (gsm.com). However, the side
effects of methylphenidate may decrease the patient’s
ability to learn.
The side effects of the drug are a major part of the
controversy that surrounds the drug. It has been
theorized that the arousal brought on by the drug may
have some effects on the patient’s sleeping patterns.
Specifically it may reduce the amount of REM sleep the
patient receives. REM sleep has been related to the
learning patterns in
subjects; that is when you reduce levels of REM sleep you
also reduce the ability to learn. The drug also has some
interactive effects with other drugs as well as with some
of the biological functions of the body. The benzene
ring constituent of the molecule can be seen as having a
major
effect in this aspect of the drug. Benzene rings are
planer structures that like to bond with other benzene
rings in a stacking type of formation. Thus when you
have methylphenidate and other drugs that have benzene
rings in their structure you tend to see that these drugs
have a tendency to interact at the benzene ring area of
the drugs. Drugs that have benzene rings in their
chemical composition are the tricyclics, the anti
coagulants, and the anticonvulsants, some of which are
MAO inhibitors
(rxlist.com).
IMAGINE THAT, THE CHEMISTRY OF RITALIN --STUDY -- MENTIONS BENZENE 9 TIMES....BENZENE CAUSES CANCER AND LEUKEMIA OF THE BONE MARROW. WHEN SPEAKING OF BENZENE RINGS....BENZENE...BENZENE SERIES...THE SIMPLEST FORM OF IT IS BENZENE, GET OUT YOUR DICTIONARY FOR THAT ONE..
NO YOUR NOT, BUT GLEN IS PHYSCO.EMZ, please excuse the stupid ramblings of our latest troll. I'm sorry you got hit twice by her and havn't had your question addressed.
You are right, in that you should be properly evaulated, and I would also suggest a thorough physcal including labs, (which include magnesium and zinc levels, which you have to ask to add) to include glucose levels, etc.
You sound like your symptoms interfere with your conteness in life. So yes I would definitly encourage you to get that eval. You do sound a bit like my son, minus the sleeplessness and weed. Best of luck to you!