I want to reply to this and address the "Meth" issue. I grew up in the 60's so i have had a very extensive drug use history. However, I always avoided "meth" because of both the propaganda/stigma associated with it, and the low life "creatures" that flocked around my friends who got into it. These people were party animals and mostly snorted and smoked it. A more out of control poster crew could hardly be imagined! Needless to say, my prejudices were off the scale.
However, once I started dating my current wife, who has a phD in neuroscience, she started pointing out behaviors in my life that were consistent with an ADD (non-hyperactive) diagnosis. Being a scientist myself, I began to research the material and take a few of the tests. The conclusions were inescapable that I had the disorder/disease. My strategies for working around these problems, like inabilty to focus, disordered schedule, intermittent projects not finished, unable to remember what I was doing etc.. were complex and not always working. As I got older, these problems just became worse. My investigations indicated that the problem stemmed from a lack of energy in the parietal lobes of the brain.
So, based upon this I decided to try a stimulant. The easiest to procure was of course methamphetamine which I purified and consumed 15 milligrams orally. Well, the results were just short of amazing. A grey cloud lifted from my personality and my intellect and I felt and finally realized what "normal" functioning people must feel. I had no jitters, buzz or anything other than a smooth, focused, upbeat day, which allowed me to understand how people without this problem could accomplish as much as they did. I got about a week's worth of projects done in that day. I had no problem sleeping and the effects persisted for 2 days afterwards, then I was back to baseline.
I then ran through the rest of the amphetamine group to see how they affected me. The straight amphetamine (benzedrine) was marginal at best with body load ( tension etc.) being uncomfortable. Adderall just made me irritable and not feel as well either, since there was appreciable body side effects from it. I did not find it allowed me to focus as well either. Clobenzorex, a diet pill from mexico that metabolizes into amphetamine and dexedrine, also had appreciable body load and side effects.
So the conclusion was that desoxyn ( meth amphetamine) in an oral dose was the most effective and the least side effects and body load of any stimulants that I tried. Given that the effects of desoxyn are a rapid release of dopamine and nor-epinepherine, I decided to add Wellbutrin to my diet to ameliorate the low dopamine I had. It got me out of the cloud and into some focus, but does not provide the motivation that nor-epinepherine does. When I take desoxyn, it does not have quite as an intense effect as it used to, due to the dopaminergic response already blocked by the Wellbutrin. However my drive and "get things done" does improve.
A caveat here on all amphetamines especially desoxyn. Most of the ecstasy studies done showing brain damage in primates were from injected (5x stronger) 800 milligram ( 80x more than 10mg) doses of methamphetamine. The principal researcher had to retract his study (ricuarte). The damage is mostly caused by dopamine being oxidized into free radicals and those active molecules entering the nerve terminals and damaging them. High doses of anti-oxidants are very important to take before, during and after your intake.
Since the wellbutrin does such a good job at maintaining base line, i only use desoxyn about 2x a week orally, and only when I have a project that needs attention. I log every usage w/ date and amount so I have an objective record. The rather interesting thing re: addiction is, that I have no desire to abuse this. I imagine that when it substitutes for what should be going on, your responses are in fact normal, without the drive/urge that party users/abusers have. This frequency of use enables me to avoid tolerance build up ( one of the fastest to do so) and still keep my life on track. Since the effects persist for 2 days for me, that is sufficient for me to feel that my life is tracking, while I continue to try and find non-pharmacological solutions to my situation.