Why AD/HDrs Like Coffeeine Soo Much | ADHD Information

Caffeine induces dopamine and glutamate release
in the shell of the nucleus accumbens
by
Solinas M, Ferre S, You ZB,
Karcz-Kubicha M, Popoli P, Goldberg SR.
Section of Preclinical Pharmacology,
Behavioral Neuroscience Branch,
National Institute on Drug Abuse,
National Institutes of Health Intramural Research Program,
Baltimore, Maryland 21224, USA.
J Neurosci 2002 Aug 1;22(15):6321-4

ABSTRACT An increase in the extracellular concentration of dopamine in the nucleus accumbens (NAc) is believed to be one of the main mechanisms involved in the rewarding and motor-activating properties of psychostimulants such as amphetamines and cocaine. Using in vivo microdialysis in freely moving rats, we demonstrate that systemic administration of behaviorally relevant doses of caffeine can preferentially increase extracellular levels of dopamine and glutamate in the shell of the NAc. These effects could be reproduced by the administration of a selective adenosine A1 receptor antagonist but not by a selective adenosine A2A receptor antagonist. This suggests that caffeine, because of its ability to block adenosine A1 receptors, shares neurochemical properties with other psychostimulants, which could contribute to the widespread consumption of caffeine-containing beverages.

I've only read the abstract so far, but does this relate in any way to research on caffeine consumption and alzheimers, parkinsons, etc.? These are, so far as I recall, dopamine related diseases, but I haven't read much about this - apparantly people who drank more coffee (2+ cups per day, I think?) were less severely affected if they got them at all. (my dad, who loves his coffee, told me about this a few weeks ago).

Hi Try,

No, I don't know. I'll go search the article after awhile. Right now I'm hungry.

David

More like a love square - I loves my diet coke too! (shh I work for Pepsi - everyone keep their mouth shut!!)I thought you were'nt into pentagrams...

Hmmm - let me see - square is four sides - penta is latin for five.

You nutter!! I'd need another mistress of drink to do that!!!

Besides - satan is our friend - haven't you seen the xtreme right xtian posts??

I love tea.  Heck I love coffee too!  Better hope they never run into each other - I'll be in suuuuch trouble!

Love triangle, eh?

I'd rather have Pat Robertson as a friend...

Well, the way I counted it, coke, pepsi, coffee, tea, well, that is four. What was the fifth? Whiskey?

what kinda coke are you implying here?   the real thing or 'the real thing'....???

Ugh - man choose your friends wiser than psycho Pattie

and again - I reiterate - FOUR!!! just FOUR!! LOL I can't drink alcohol - not unless I want to bleed to death.  Bad stomach.

 

is there diet cocaine? for the calorie conscious junkie? I did say diet coke right?Hey, the real thing was in the real thing. It was on PBS the other night. Vin Mariani. Twas a good vintage...

yeah thats wayy to long for me to read

David's first independent post.

OMG!...I didn't even post in blues back then!!!

*ack! and I used such large fonts!

But what a font of info...

ooooooo, that's creeeeepy....

Yeah! We should drink

"Tea, Earl Grey, Hot"

~Jean-Luc Picard~

well i say --- make coffee illegal!!!!!!

all these people going around drugging themselves every day with caffeine it's an outrage!